Vitaly Kimovich
Koltover
Sci. D., Ph.D
Bio-Reliability
Group, Institute of Problems of Chemical Physics, Russian Academy of
Sciences (IPCP RAS), Chernogolovka, Moscow Region, 142432, Russia
Date of birth:
15-May-1944
Affiliation and
official address
Bio-Reliability Group, Institute of Problems of Chemical Physics,
Russian Academy of Sciences (IPCP RAS), Chernogolovka, Moscow Region,
142432, Russia.
E-mail:
koltover@icp.ac.ru
Education
1961:
Graduated from High School #14, Kiev, Ukraine (former USSR).
1966:
National Taras Shevchenko State University, Department of Physics,
Master Degree - Physics (Diploma with Honor), Kiev (Ukraine – former
SU). Thesis: “EPR of gamma-irradiated amino-acids and proteins”,
advisor: Prof. D.M. Grodzinsky.
1971: Ph.D.
(Candidate of Physical and Mathematical Sciences – Chemical Physics),
Institute of Chemical Physics, USSR Academy of Sciences, Moscow. Thesis:
"Studies of the electron-transport biological membranes by the molecular
probes", advisor: Prof. L.A. Blumenfeld.
1988: Sc.D.
(Doctor of Biological Sciences – Biological Physics), Highest
Attestation Committee, Moscow. Thesis: "Reliability of
electron-transport membranes and the role of oxygen anion-radicals in
aging".
Employment
1966 (Sep.) – 1968 (Nov.):
Research Fellow in Biophysics, Department of Radiation Biology,
Institute of Plant Physiology, Ukrainian Academy of Sciences, Kiev.
1968 (Dec.) – 1971 (Nov.):
Pre-doctoral Fellow (Aspirant), Institute of Chemical Physics, USSR
Academy of Sciences, Moscow.
1972 (Jan.) – Present: Junior
Scientist, Senior Scientist, since 1992 – Leading Scientist, Institute
of Problems of Chemical Physics, Russian Academy of Sciences (former
Branch of the Institute of Chemical Physics of the USSR Academy of
Sciences), Chernogolovka, Moscow Region.
Main fields of experience
1964 – Present: Reliability and
aging of biological systems, free radicals and antioxidants, spin
biochemistry and biophysics, endofullerenes, nanoparticles.
Professional societies and committees
Advances in Gerontology
(international journal, editor, St-Petersburg); Problems of Aging and
Longevity (international journal, editor, Kiev); American Chemical
Society; International Union of Radioecology; Russian Biophysical
Society; Russian Society of Gerontology; Committee on Reliability of
Biological Systems” at the Scientific Council on Biophysics of the USSR
Academy of Sciences, vice-chairman (1978-1992).
Listings
American
Biographical Institute; Cambridge International Biographical Centre;
Marcus Who’s Who, Biophysics of Russia.
Lecturing and research abroad
2004 (November): Max-Planck
Institute for Demographic Research, Rostock (Germany).
2002 (June): National Lawrence
Berkeley Laboratory, University of California, Berkeley, (USA).
2002 (January-February): Indian
Institute of Technology, Chennai (Madras) and Bhabha Atomic Center,
Mumbai (India).
2001 (July): Department of
Chemistry, Northwestern University, Evanston (USA).
1991 (July) – 1992 (June):
Institute of Pharmacology and Toxicology, University of Veterinary
Medicine, Vienna (Austria).
1990 (November-December):
Department for Biochemistry and Biophysics, University of Pennsylvania,
Philadelphia (USA).
1989 (February): National
Lawrence Berkeley Laboratory, University of California, Berkeley, (USA).
Representative Publications (selected from more than 200 papers).
Books
Kutlakhmedov, Y.A., Korogodin, V.I., and Koltover, V.K.
“Foundations of Radiation Ecology”. Kiev: Vyshcha shkola, 2003. 320 P.
(Ukraine).
Grodzinsky,
D.M., Vojtenko, V.P., Kutlakhmedov, Y.A., and Koltover, V.K.
“Reliability and Aging of Biological Systems”. Kiev: Naukova Dumka,
1987. 172 P.-book (Russ.).
Book chapters
Koltover,
V.K. Theory of reliability and biological
aging: From analogy to knowledge. In: MMR 2009 – Mathematical Methods In
Reliability. Theory. Methods. Applications. VI International Conference,
Moscow: Gubkin Russian State University of Oil and Gas, 2009,
pp.482-486.
Koltover,
V.K. Reliability of nano devices and
systems: Nuclear spins of stable magnetic isotopes as the reliability
factors of biomolecular nanoreactors.
In: “Nanotechnology 2008”, Vol. 1, Danville (CA, USA): Nano Science and Technology Institute,
2008, pp. 254-257.
Koltover,
V.K. Endohedral fullerenes: from chemical
physics to nanotechnology
and nanomedicine. In: “Progress
in Fullerene Research” (Ed.
M. Lang), New York: Nova Science
Publishers, 2007, pp.
199-233.
Koltover,
V.K. Free radical theory of aging:
Quantitative reliability aspects and antioxidant intervention. //Vienna
Aging Series, Vol.5: Vitality, Mortality and Aging (ed. A.Viidik and
G.Hofecker), Vienna: Facultas, 1996, pp. 173-180.
Koltover,
V.K. Free radical theory of aging: View
against the reliability theory. //Free Radicals and Aging (Ed. I. Emerit
and B. Chance), Basel: Birkhauser, 1992, pp. 11-19.
Koltover,
V.K. Use of the spin-probe method in
membrane biophysics. //Biophysics, Vol. 4 (Methods used to study the
structure of biological membranes), Boston: G.K. Hall and Co., 1977, pp.
10-68.
Refereed journals
Koltover,
V.K. Bioantioxidants: The systems
reliability standpoint. //Toxicology and Industrial Health. 2009, 25
(4-5), 295-299.
Koltover,
V.K. Endofullerenes: from chemical physics
to base elements for nanotechnologies and nanomedicine. //Ross. Khim.
Zhurn. 2009, 53 (2), 79-85.
Koltover,
V.K. Theory of reliability and aging:
stochastic realization of the genetic program. //Problems of Aging and
Longevity. 2009, 18 (1), 26-31 (in Russian).
Koltover,
V.K. Nuclear spin catalysis in
free-radical biology: antioxidant effects of magnesium–25. //Free
Radical Biology and Medicine. 2008, 45, S. 12.
Goncharova,
N.D, Shmaliy, A.V, Bogatyrenko, T.N., Koltover, V.K. Correlation
between the activity of antioxidant enzymes and the circadian rhythms of
corticosteroids in Macaca mulatta monkeys of different age.
//Experimental Gerontology. 2006, 41(8), 778-783.
Koltover,
V.K. Nanoparticles of endohedral
metallofullerenes. //Journal of Molecular Liquids. 2006, 127, 139-141.
Koltover,
V.K. Preservation of endometallofullerene
La@C82 in polycarbonate: EPR, ENDOR and NMR studies.
//Journal of Molecular Liquids. 2005, 120 (1-3), 151-154.
Koltover,
V.K. Endohedral metallofullerenes: Stabilization, clustering and
spin-leakage. //Chinese J. Light Scattering. 2005, 17 (3), 248-250.
Koltover,
V.K. Reliability of electron transport in
biological systems and the role of the oxygen free radicals in aging.
//Control Sciences. 2004, N 4, 40-45 (Russ.).
Koltover,
V.K., Logan, J.W., Heise, H., Bubnov,
V.P., Estrin, Y.I., Kareev I.I., Lodygina, V.P., Pines, A. Diamagnetic
clusters of paramagnetic endometallofullerenes: A solid state MAS NMR
study. //J. Phys. Chem. B. 2004, 108 (33), 12450-12455.
Koltover,
V.K. Spin-leakage of the fullerene shell
of endometallofullerenes: EPR, ENDOR and NMR evidences. //Carbon. 2004,
42 (5/6), 1179-1183.
Nath, S.,
Pal, H., Sapre, A.V., Bubnov, V.P., Estrin, Y.I., Parnyuk, T.A. &
Koltover, V.K. Aggregation of endometallofullerene Y@C82
in polar solvents. //Fuller. Nanotub. Car. N. 2004, 12 (1), 53-57.
Koltover,
V.P., Bubnov, V.P., Estrin, Y.I., Lodygina,
V.P., Davydov, R.M., Subramoni, M., Manoharan, P. T. Spin-transfer
complexes of endohedral metallofullerenes: ENDOR and NMR evidences.
//Phys. Chem. Chem. Phys. 2003, 5 (13), 2774-2777.
Koltover,
V.K. Towards the novel metallofullerene-based
probes for EPR, NMR and nuclear medicine. //Indian J. Chem., Sec. A.
2002, 41A (1), 94-95.
Bubnov,
V.P., Laukhina, E.E., Kareev, I.E., Koltover, V.K., Prokhorova,
T.G., Yagubskii, E.B., Kozmin, Y.P. Endohedral metallofullerenes: A
convenient gram-scale preparation. //Chem. Mater. 2002, 14 (3),
1004-1008.
Koltover,
V.K., Parnyuk, T.A., Bubnov, V.P.,
Laukhina, E.E., Estrin, Y.I., Yagubskii, E.B. Stability and mobility of
the endohedral metallofullerene La@C82 in polycarbonate
polymer films. //Phys. Sol. State. 2002, 44 (3), 529-530.
Koltover,
V.K. Free radical theory of aging: An
historical synopsis. //Advances in Gerontology (St. Petersburg). 2000,
4, 33-40 (Russ.).
Koltover,
V.K. Reliability concept as a trend in
biophysics of aging. //J. Theor. Biol. 1997, 184 (2), 157-163.
Koltover, V.K. Reliability of
electron-transport membranes of mitochondria and the role of superoxide
radicals in aging. //Chem. Phys. Rep. (Khimicheskaya Fizika, Moscow).
1996, 15 (1), 109-115.
Koltover, V.K. Radon irradiation: sources,
doses, and biological effects. //Herald of the Russian Academy of
Sciences. 1996, 66 (2), 114-119.
Koltover, V.K. The antihypoxic action of
antioxidant BHT mediated via nitric-oxide: A study of EPR signals in
tissues of rats of different ages. //AGE (J. Amer. Aging. Ass.). 1995,
18 (3), 85-89.
Nohl, H.,
Koltover, V., Stolze, K. Ischemia/reperfusion impairs
mitochondrial energy conservation and triggers O2ˉ
release as a by-product of respiration. //Free Radical Res. Comms. 1993,
18 (3), 127-137.
Koltover,
V.K., Andrianova, Z.S., Ivanova, A.N.
Simulation of survival and mortality curves of human populations based
on the theory of reliability. //Biology Bulletin of Russian Academy of
Sciences. 1993, No. 1, 121-129.
Estrin, Y.I.,
Kasumova, L.T., Koltover, V.K. Analysis of the functionality
types distribution and mechanism of formation of hydroxyoligobutadiene
by polymerization with the lithium initiator. //Polymer Science (Vysokomol.
Sojedin. A, Moscow). 1991, 33 (11), 2283-2287.
Koltover,
V.K., Gerasimovich, N.V., Kirilyuk, A.P.,
Milyutin, A.A., Romanov, S.G. Age-specificity of lipid fluidity in rat
heart sarcoplasmic reticulum membranes. //Bull. Exp. Biol. and Med. -
English Trans. 1989, 108 (10), 1419-1421.
Frolkis, V.V., Nikolaev, V.G.,
Paramonova, G.I., Shcherbitskaya, E.V., Bogatskaya, L.N., Stupina, A.S.,
Kovtun, A.I., Sabko, V.E., Shaposhnikov, V.M., Muradian, Kh.K., Adamenko,
N.P., Novikova, S.M., Koltover, V.K., Gorban, E.N. Effect of
enterosorption on animal lifespan. //Biomaterials, Artificial Cells, and
Artificial Organs. 1989, 17 (3), 341-351.
Gus'kova,
R.I., Ivanov, I.I., Koltover, V.K., Akhobadze, V.V., Rubin, A.B.
Permeability of bilayer lipid membranes for superoxide (O2ˉ).
//Biochim. et Biophys. Acta. 1984, 778, 579-585.
Koltover,
V.K. Theory of reliability, superoxide
radicals and aging. //Russian Adv. Modern. Biol. (Uspekhi Sovremennoj
Biologii). 1983, 96 (4), 85-100.
Koltover, V.K. Reliability of enzyme systems and molecular
mechanisms of ageing. //Biophysics (Moscow). 1982, 27 (4), 635-639.
Koltover,
V.K. Reliability of enzymatic protection
of a cell against superoxide radicals and aging. //Doklady Biophysics (DOKL
AKAD NAUK SSSR, contributed by N.N. Semenov). 1981, 256 (1), 3-5.
Koltover,
V.K., Kutlakhmedov, Y.A., Afanaseva, E.L.
Recovery of cells from radiation-induced damages in the presence of
antioxidants and the reliability of biological systems. //Doklady
Biophysics. 1980, 254, 159-161.
Koltover,
V.K., Reichman, L.M., Yasajtis, A.A.,
Blumenfeld, L.A. A study of spin-probe solubility in mitochondrial
membranes correlated with ATP-dependent conformation changes. //Biochim.
et Biophys. Acta. 1971, 234, 296-310.
Koltover,
V.K., Goldfeld, M.G., Hendel, L.Y.,
Rozantsev, E.G. Conformation transition in biological membrane studied
by the spin label method. //Biochem. Biophys. Res. Communs. 1968, 32,
421-425.
Oral presentations at international scientific meetings
Theory of
reliability and biological aging: from analogy to knowledge. 6th
International conference “Mathematical Methods in Reliability”
(MMR-2009), Moscow, Russia, 22-27 June 2009.
Stable
isotope of magnesium-25 as micronutrient
antioxidant. 3rd International Symposium on
Nutrition, Oxygen Biology & Medicine, Paris, France, 8-10 April
2009.
Spin
catalysis in molecular liquids and biomolecular nano-reactors. “Physics
of Liquid Matter: Modern Problems – the 4th International
Conference and Strategic Workshop Nanoscale Liquid Systems”, May 23-26,
Kyiv, Ukraine, 2008.
Endohedral
fullerenes: from chemical physics to nanoengineering and nanomedicine.
3rd International Conference on Optoelectronics and Spectroscopy of Nano-Structured
Thin Films and Materials (ICOSFM’2007), October 15-19, Beijing, P.R.
China, 2007.
Antioxidant
therapy of aging: the systems reliability overlook. VI European Congress
of International Association of Gerontology and Geriatrics (In the
framework of the United nations Research Agenda on Ageing for the 21st
Century), Saint-Petersburg, Russia, July 5-8, 2007.
Aging
versus reliability: stochastic free-radical modulations of the
programmed genetic melodies. VI European Congress of International
Association of Gerontology and Geriatrics (In the framework of the
United nations Research Agenda on Ageing for the 21st Century),
Saint-Petersburg, Russia, July 5-8, 2007.
Antioxidants: trapping free radicals or modulating system reliability?
3rd International conf. on oxidative stress in skin biology and
medicine, Andros, Greece, September 21-24, 2006.
Antioxidants as the mild stressors: reliability-theory point of view.
“Nutrition, Oxygen Biology and Medicine” (meeting of SFRR Europe –
Oxygen Club of California), Paris, France, March 2-4, 2005.
Endohedral
Metallofullerenes: Stabilization, Clustering and Spin-Leakage. The
International Conference on Optoelectronics and Spectroscopy of Nano-Structured
Thin films and Materials (ICOSFM’2004), Beijing, P.R. China,
August 1-6, 2004.
Spin-leakage of the fullerene cage of endometallofullerenes: EPR, ENDOR
and NMR evidences. E-MRS Spring Meeting - Symposium on Advanced
multifunctional nanocarbon materials and nanosystems, Strasbourg,
France, June 10-13, 2003.
Towards the
novel metallofullerene-based probes for electron paramagnetic resonance,
nuclear magnetic resonance and nuclear medicine. International symposium
“Biomedical Magnetic Resonance” (NMR-2002), Lucknow, India,
January 20-24, 2002.
Aging
versus reliability: Stochastic modulations of genetic melodies. 17th
World Congress of the Inter. Ass. of Gerontology, Vancouver, Canada,
July 1-6, 2001.
Endohedral
metallofullerenes: The new molecular paramagnetic probes for EPR
oxymetry. XVIII Inter. Conf. on Magnetic Resonance in Biological
Systems, Tokyo, Japan, August 23-28, 1998.
Aging and
reliability. Inter. Symposium “Superoxide Dismutases: Recent Advances
and Clinical Applications”, Paris, France, May 14-15, 1998.
The
indirect antioxidant regulation mediated via nitric-oxide: ESR and
hormonal measurements of the effects of BHT. Inter. Symposium “Oxidative
Stress and Redox Regulation: Cellular Signaling, Aids, Cancer and Other
Diseases”, Paris, France, May 21-24, 1996.
Stimulation
of transcription in mouse liver cells by nitric-oxide radicals. “Free
Radicals: from Basic Science to Medicine” (VI Biennial Meeting),
Turin, Italy, June 16-20, 1992.
Reliability
of biological systems at different organization levels and the problem
of molecular mechanisms of aging. 20th Annual Meeting of the
American Aging Association, New York, USA, October 3-6, 1990.
